Weak organic acids pH 3-5
Most NSAIDs are greater than 95% protein bound
NSAIDS are metabolized primarily in the liver
Conjugate metabolite urine
They vary in their half-live and bioavailability
Variability of their half-live allows for different dosing regimens
Increase in renal dysfunction associated with longer-acting NSAIDs
Clearance up to age, type of animal.