During SE, brain damage has been observed most often in the cortex, but sometimes also in other structures, even the spinal cord [17]. The most frequent changes in the brain are ischemic lesions, especially in the autonomic system nuclei. Perivascular edema, swelling of astrocyte endfeet, and signs of apoptosis may be observed. Neurons have shrunken nuclei and damaged cell membranes [74], and astrocytes, microglia, and perivascular macrophages show a high degree of activity [91], which undoubtedly is evidence of an inflammatory process.