As shown in Table 2, the serum ASAT and ALAT activities were significantly increased (P < 0.05) following administration of CP as compared to control group. While, serum total protein and activity of ALP decreased significantly (P < 0.05) after CP administration. However, treatment with MPS (500, 1000 mg/kg) and/or silymarin decreased significantly the serum ASAT and ALAT activities. On the other hand, MPS (500, 1000 mg/kg) and/or silymarin significantly increased serum total protein and activity of ALP.