Three potential mechanisms may account for the effect
of Bifidobacterium lysate on skin sensitivity: (i) a direct
action by inhibiting the release of neuro-mediators
involved in sensitivity phenomena as shown by capsaicin
test on neurone culture; (ii) a direct action by decreasing
neurogenic inflammation frequently associated with sensi-
tive skin symptoms as suggested by data from human skin
organ culture following SP stimulation, and (iii) an indirect
action by improving skin barrier function and protecting
neurones from external stimuli, as suggested by clinical
assessment of barrier function using the tape stripping
method