It has been shown that the GSPs can inhibit the UVB-induced activation of NF-jB through inhibition of degradation of IjBa and activation of IjB kinase a. Using an identical mouse model, it has been further demonstrated that the dietary administration of
GSPs resulted in the inhibition of the expression of PCNA, cyclin D1, iNOS and COX-2 in the skin, which are NF-jBtargeted proteins