A simple fluorescence method was developed for the direct
determination of celecoxib in capsules. The capsules were emptied,
pulverized and dissolved in either ethanol or acetonitrile,
sonicated and filtered. Direct fluorescence emission was measured
at 355 ± 5 nm (exciting at 272 nm). The method was
fully validated and the recoveries were excellent, even in presence
of excipients (Damiani et al., 2003).