Interventional radiology (IR) proceduralists (IRPs) perform increasing numbers and types of complex invasive procedures. A multisociety guideline published in 2012 is a great resource for IPs and IR departments, describing key infection prevention priorities for these complex procedures.Most IRPs perform percutaneous procedures, and many procedures involve an implant. Procedures involving implants are associated with greater risk of infection because of the potential for biofilm formation.Implants include IV ports, aortic valves, cardiac stents, thoracic stents, internal automatic defibrillators, and cardiac pacemakers. Infrequent but significant morbidity and reoperation is reported when infections occur after placement of these implants.Many patients undergoing IR procedures are at high risk for infection even before the procedure because of comorbidities or the emergent nature of their treatment. For instance, IRPs often place vascular ports in oncology patients for chemotherapy infusions, and these immunosuppressed patients are at high risk for infection. These grafts are used to treat incomplete aortic injuries and carry much lower morbidity and mortality than open surgery; however, there is still infection risk. Infection prevention measures for percutaneous procedures are the same as those for central venous vascular access, including the use of a dual-agent skin prep (ie, products that include alcohol combined with another antiseptic),aseptic technique during percutaneous entry,full PPE precautions by the IRP, and aseptic technique during the procedure.