Viremia subsides with the appearance of humoral antibody, and the host recovers unless a specific target organ is affected.
This target organ—the liver in Rift Valley fever, the brain in La Crosse encephalitis, the liver and vascular endothelium in Crimean-Congo hemorrhagic fever and hemorrhagic fever with renal syndrome, and the lung in hantavirus pulmonary syndrome—is damaged, and a specific disease occurs.