Based on this fact, Tang et al. (2011) constructed a time-course network with gene expression data and the result indicated that the performance of identifying functional modules based on the time-course PPI network is better
than that based on a static PPI network. Wang et al. (2013) built a new dynamic PPI network using a method similar to that adopted by Tang et al. (2011) and concluded that the dynamic PPI network can contribute to the discovery of protein complexes. The main difference between the two approaches is the process of selecting the active threshold of proteins.