Explored how curcumin might be valuable in treating diabetes, finding that it activates AMPK (which increases glucose uptake) and suppresses gluconeogenic gene expression (which suppresses glucose production in the liver) in hepatoma cells. Interestingly, they found curcumin to be 500 times to 100000 times (in the from known as tetrahydrocurcuminoids(THC)) more potent than metformin in activating AMPK and its downstream traget acetyl-CoA