Halotolerant and halophilic marine myxobacteria are poorly in- vestigated regarding secondary metabolite production. There- fore, the pool of secondary metabolites isolated from organisms of this kind is very low to date, when compared to that of their terrestrial counterparts. This is mainly due to the difficulties that are encountered during isolation and cultivation processes of marine myxobacteria. However, herein we intend to show that these organisms are a great research niche, which offers the op- portunity to find novel bioactive compounds with the potential to become drug leads.