Although the first clinical case of PGD was reported in the
literature in 1992 [13], PGD has only recently begun to be progressively
accepted in Taiwan. Starting with our first case reported
in 2004 [6], we have collected information on 38 cycles of reciprocal
and Robertsonian translocation carrier couples, in which 28
cycles received embryo biopsies. The overall mean maternal age
was 34.9 years. Worldwide, chromosome rearrangements have
been an indication for PGD for a number of years [14]. According to
the latest published data collected for the calendar year 2007 by the
European Society for Human Reproduction and Embryology
(ESHRE) PGD consortium [15], there were 644 cycles to OPU for
reciprocal translocation or Robertsonian translocation carriers. In
the reciprocal translocation group seeking PGD help, the live delivery
rate was 13.6% per OPU cycle and 23.9% per ET cycle. In the
Robertsonian translocation group, the live delivery rate was 22.1%
per OPU cycle and 32.1% per ET cycle. By comparison, our results
showed a live delivery rate of 8.3% per OPU cycle and 18.2% per ET
cycle for the reciprocal translocation group. Furthermore, the live
delivery rate for the Robertsonian translocation group was 14.3%
per OPU cycle and 20.0% per ET cycle. One possible reason for these
poorer results is that the mean female age of our patients is slightly
higher than that of the ESHRE PGD consortium (34.9 years vs. 34
years). Alternatively, the limited case number might also be a factor.
Although the first clinical case of PGD was reported in theliterature in 1992 [13], PGD has only recently begun to be progressivelyaccepted in Taiwan. Starting with our first case reportedin 2004 [6], we have collected information on 38 cycles of reciprocaland Robertsonian translocation carrier couples, in which 28cycles received embryo biopsies. The overall mean maternal agewas 34.9 years. Worldwide, chromosome rearrangements havebeen an indication for PGD for a number of years [14]. According tothe latest published data collected for the calendar year 2007 by theEuropean Society for Human Reproduction and Embryology(ESHRE) PGD consortium [15], there were 644 cycles to OPU forreciprocal translocation or Robertsonian translocation carriers. Inthe reciprocal translocation group seeking PGD help, the live deliveryrate was 13.6% per OPU cycle and 23.9% per ET cycle. In theRobertsonian translocation group, the live delivery rate was 22.1%per OPU cycle and 32.1% per ET cycle. By comparison, our resultsshowed a live delivery rate of 8.3% per OPU cycle and 18.2% per ETcycle for the reciprocal translocation group. Furthermore, the livedelivery rate for the Robertsonian translocation group was 14.3%per OPU cycle and 20.0% per ET cycle. One possible reason for thesepoorer results is that the mean female age of our patients is slightlyhigher than that of the ESHRE PGD consortium (34.9 years vs. 34years). Alternatively, the limited case number might also be a factor.
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