Wineries and laboratories are hazardous environments and those who use or manage them have a duty of care to others within the site. They are required by law to adopt safe working practices and to maintain a safe working environment. This chapter outlines the principal areas of concern: safe handling and storage of chemicals and solvents; developing safe work practices for confined environments; and electrical and mechanical safety. It also provides a guide to documentation for materials safety (chemicals and solvents, principally) and the need to document and train students and staff in safe operational practices for machinery and processes. It should be read in conjunction with local regulations and law, which will take precedent. The chapter emphasizes the importance of developing a culture of individual responsibility for personal safety.