Wound healing is a process of restoring damaged cells
and tissues.5-7 The phases of wound healing occur in a
precise and regulated order. Firstly, it involves hemostasis
and inflammation; secondly, mesenchymal cells differentiate,
proliferate, and migrate to the wound site;
thirdly, angiogenesis and epithelial deposition at the
wound surface site. Finally, synthesis, cross-linking and
alignment of collagen is required to provides structural
strength to the wound healing tissue.8 The wound also
undergoes physical contraction, which might be mediated
by contractile fibroblasts.9 Neuropeptide Substance
P (SP) is a pro-inflammatory neuropeptide, and
modulates inflammatory responses of skin wounds. SP
also promotes the synthesis and metabolism of fibroblast
and increases accumulation of collagen in the proliferative
phase of mesenchymal cell growth and dynamics.
10 In addition, SP is an important medium in
the process of wound repair and scar healing.