Using in vitro study, Iordache
et al. (2008) have demonstrated that cell-free cultures of
lactic acid bacteria with probiotic potentials including
Lactobacillus plantarum, Lactobacillus casei and Enterococcus faecium inhibited the expression of soluble virulence
factors by opportunistic dermal pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa and
decreased their adherence capacity to the cellular substrate represented by HeLa cells. Meanwhile, using ex vivo
human skin explants model, Gueniche et al. (2010) found
a statistically significant (P < 005) improvement following application of cell lysate from Bifidobacterium longum
sp. versus placebo in various parameters associated with
inflammation such as a decrease in vasodilation, oedema,
TNF-alpha release and mast cell degranulation. The
potentials of probiotics in dermal application have also
been evaluated in several in vivo studies (Table 2).