Table IV showed that lung cancer risk following a lifetime of exposure at the current OSHA standard of 0.1mg/m3 is likely to be increased by 30% or more. The shape of the exposure±response curve for lung cancer is unknown. It is customary to assume a linear dose±response pattern for regulatory purposes [Peto, 1979], but if silicosis plays a role in the causal pathway, the lung cancer exposure±response relation might be nonlinear, as it is for silicosis. The exposure±response relation in the paper of Checkoway and colleagues [Checkoway et al., 1998] is consistent with a sigmoidal relation, but the data are inadequate to de®ne the shape of the curve. Radiographic silicosis is a marker for lung cancer risk [Finkelstein, 1998] so that reducing dust exposures to lower the risk of silicosis will decrease the risk of lung cancer as well.
Table IV showed that lung cancer risk following a lifetime of exposure at the current OSHA standard of 0.1mg/m3 is likely to be increased by 30% or more. The shape of the exposure±response curve for lung cancer is unknown. It is customary to assume a linear dose±response pattern for regulatory purposes [Peto, 1979], but if silicosis plays a role in the causal pathway, the lung cancer exposure±response relation might be nonlinear, as it is for silicosis. The exposure±response relation in the paper of Checkoway and colleagues [Checkoway et al., 1998] is consistent with a sigmoidal relation, but the data are inadequate to de®ne the shape of the curve. Radiographic silicosis is a marker for lung cancer risk [Finkelstein, 1998] so that reducing dust exposures to lower the risk of silicosis will decrease the risk of lung cancer as well.
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