Primary Disease Symptoms:
• Abrupt onset of fever and chills with myalgia, malaise,
and headache
• Multisystem involvement follows that includes
prostration; nausea, vomiting, abdominal pain, diarrhea
and pancreatitis; chest pain, cough, and
pharyngitis; vascular and neurologic manifestations.
• Around Day 5, most patients develop a maculopapular
rash that is prominent on the trunk followed by
desquamation in survivors.