In Cardcaptor Sakura, she is the girl chosen to become the new mistress of the magical Clow Cards after Clow Reed, the creator of the Clow Cards and the guardians (Yue and Cerberus), had died. The story develops on Sakura's quest to capture all of the fifty-two Clow Cards, and later on, converting them into Sakura Cards with her own magical power of the stars.
In xxxHolic, Yuko states that Sakura has a boyfriend/sweetheart (Syaoran) that she is currently living with. Sakura gave Syaoran's mother her Star Wand in a dream so that she (Syaoran's mother) could give it to Yuko as the price for the real Syaoran to go to Clow Country after she had a dream that "Syaoran" would meet with his destined person.
Prior to this, Sakura had made a cameo appearance in Tsubasa Chronicle: Tokyo Revelations as a spirit of the feather that Fuuma had, who guided Princess Sakura back to the group. Fans made many speculations, asking whether this meant she was dead or was communicating with her other self. (This happens only in the OVA)