Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which
include cancer, inflammation, and infection.The aim of this reviewis to report the pharmacological potential of plants of Clusiaceae
family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating
anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and
Embase. In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.” Results. A total
of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the
final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory
activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma
formation, and paw or ear edema formation. Other interesting findings included decreased of theMPO activity, and inflammatory
mediators such as NF-