Hg and Sewere the main mining elements in theWanshan Hg mine, and As, Sb, Pb and Zn were the main mineralization-associated elements. Hg, Se and As significantly correlated with each other and were the main pollutants. High blood As, Se, THg and MeHg concentrations at site A, D and E resulted from environmental pollution caused by Hg mining activities. In this study, we focused on Hg and Se exposure and their interactions.