Only a limited number of studies investigating the prevalence of MRSA in the food chain in the US were conducted in the last few years [17]. The number of studies discussing the prevalence of S. aureus in beef livers is very limited in the literature [30]. The objectives of this study were to determine the prevalence of Staphylococcus aureus and MRSA in retail beef livers, beef, and pork meats sold in the Tulsa, Oklahoma area and to characterize the recovered strains for their virulence and antimicrobial resistance.