Acute pneumotoxicity of styrene is evidently supported
by animal studies. However, limited information
is known regarding the biochemical mechanism
of acute cytotoxicity induced by styrene. The objectives
of the present study were to examine the role of
CYP2E1 in styrene toxicity, to identify styrene oxide as
a metabolite of styrene, to confirm CYP2E1 is responsible for the formation of oxide metabolite of styrene,
and to verify the cytotoxic effect of styrene oxide
metabolite.