The microwave vacuumed durian chips contained 2.07–3.01% fat content (Table 7). There was no significant (p > 0.05) impact of pretreatment and drying condition on fat content of the dried durian chips. Compared with commercially fried durian chips (32.19–36.54% fat content), the microwave vacuum drying process reduced the fat content of the durian chips by at least 90%. With the additional benefits of retaining natural color and having a porous structure and comparable texture, microwave vacuum drying, therefore, could be considered as an alternative process to produce low-fat durian chips.