Signaling pathway in cancer
cancer cells is genetic alterations change the flow of information through the normal signal-cue-response model, resulting in the disease phenotype. Alterations that perturb the network include DNA mutations, amplifications, or changes in copy number, as well as changes in gene expression through epigenetic regulation or mRNA splicing. - See more at: http://www.cellsignal.com/contents/science/cancer-research/cancer-research#sthash.KaTE4FTH.dpuf