he epidermis as well as the dermis are becoming thinner and the dermoepidermal junction flattens. Whereas the predominant feature of aged dermis is the reduction and fragmentation of the extracellular collagen matrix, in the epidermis the turnover rate of the keratinocytes slows down considerably and the protein composition of the cornified envelope responsible for the barrier function changes dramatically (Rinnerthaler et al., 2013). In this review we are focusing on changes in the epidermis during aging, for the dermis we refer to other reviews (Farage et al., 2013, Makrantonak