The purpose of this study is to determine the effect of the enzymes issue discussed through the theory of Multiple Intelligences to the success of students. For this purpose, considering the final achievement test scores performed immediately after the subject of enzymes discussed with activities based on the traditional approach and on the theory of Multiple Intelligences; it can be observed that the mean success scores of both of the student groups have increased compared to the pre-test. However, it is seen that this increase has been higher in the experimental group in which activities based on the theory of multiple intelligences have been held. In this respect, the theory of Multiple Intelligences can be said to be effective in learning