Heavy sedation, delirium, and immobility are the main risk factors for PICS. Others include sepsis, hypoxia, and hypoglycemia. After assessing the patient’s and family’s risk factors for PICS and PICS-F respectively, the ICU team should implement strategies to mitigate them. The ABCDE bundle is a group of interventions that addresses the risks of sedation, delirium, and immobility. This tool supports the new guidelines on pain, agitation, and delirium published by the Society of Critical Care Medicine (SCCM).