We calibrated age-specific relative risks to be within 0.02 of these estimates and overall relative risks within the 95% confidence intervals for the summary estimates from a large meta-analysis of randomized clinical trials of hypertension treatment (see the Methods section and Tables S2 and S3 in the Supplementary Appendix).9 We validated the resulting assumptions with respect to relative risk for the treatment of systolic blood pressure in patients between the ages of 60 and 74 years by simulating the treatment and placebo groups of the Systolic Hypertension in the Elderly Program (SHEP) trial13 and comparing simulated relative risks with those observed in the trial (Table 2, and Table S4 in the Supplementary Appendix).