To implicate the molecular pathways impacted by DENV-2
infection, proteins of DENV-infected and mock-infected 293T cells
were extracted and prepared for iTRAQ analysis. DDX21 was
identified in the down-expression group in infected cells for the
first time (Table 1). We confirmed the change in DDX21 expression
in A549 cells infected with DENV-2 and harvested at 12 h intervals.
DDX21 expression was significantly reduced over the first day and
rebounded after 36 h post-infection (Fig. 1).