program. With the utilization of the CapNMRe probe,
new opportunities have been created to take the sample
requirements down to the microgram scale, allowing
structure elucidation without the need to recollect and
scale up, thus accelerating the process. Full NMR data
set acquisitions on single digit microgram scale are
now possible. However, a time constraint still exists in
working with large numbers of active pure and semi
pure natural product isolates, creating additional roadblocks
in working with compounds from natural
sources. New methodologies will still need to be
exploited in order to accelerate the process further.
Implementing intelligent structure elucidation software
could provide a new tool to speed the structure elucidation
process. Routine high-resolution mass spectra, providing
accurate mass on all samples could also facilitate
the process. What we have clearly demonstrated in this
paper is a tremendous step toward the rapid isolation
and structure elucidation of active compounds from a
natural product mixture, thus reinvigorating the field
of natural products into high-throughput screening
regimes.