Gupta and Dixit [73] used the vesicular system for delivery
of curcumin to achieve enhanced topical bioavailability and to
attain significant antioxidant and antiaging effect. The combination
of curcumin with phosphatidyl choline was prepared
and converted into phyto-vesicles. Liposomes and niosomes of
curcumin were also prepared and all these vesicular formulations
were incorporated into carbopol gel to make topical
application feasible. The phyto-vesicles were found to be most
effective compared to all other formulations and plain curcumin
in providing enhanced antioxidant and antiaging effect.
This increase may be due to the amphiphilic nature of the
complex, which greatly enhances the water and lipid miscibility
of the curcumin. This indicates the superiority of phytovesicles
prepared from curcumin-phosphatidyl choline complex
in providing enhanced antiaging, antioxidant, and antiwrinkle
effect [73].