have detectable levels
of urine IgG to adult OV antigen extract. Moreover, elevated
levels of urine IgG to OV antigen were not associated with either
the intensity of OV infection (as measured by fecal egg counts) orthe levels of serum antibodies to OV antigen.
These findings support our hypothesis that urine IgG to OV antigen most likely
represents renal pathology in the form of immune complexmediated
structural damage to the glomeruli (injury of podocytes)
and to the tubular interstitium as observed in animal models of OV infection [10,11].