Although gps do not succumb to infection with wild-type EBOV
and an adapted variant has been utilized in its place, the hallmarks
of GA-EBOV infection in gps are quite comparable to wild-type
EBOV infection in NHPs. Taken together, IN vaccination with
Ad5-based EBOV vaccines is an effective countermeasure against
disease caused by EBOV spread between susceptible hosts and
has the potential to prevent the occurrence of new infections during
an EBOV outbreak.