Outcome parameters
Primary outcome
Survival without BPD at 36 weeks postmenstrual age (PMA).
Secondary outcomes
1.
Resuscitation: Apgar score at 5 min, time after birth to achieve SpO2 > 88% and cumulative O2 exposure during resuscitation.
2.
Oxidative stress: Glutathione (GSH) synthesis and oxidative stress markers
3.
Incidence of ROP and brain injury.
4.
Neurodevelopmental outcome at 2 years of age.
The timeline of the study design is depicted in Figure 2.