Results: The extracts of P. pseudocaryophyllus evaluated showed expressive results regarding the inhibition
of xanthine oxidase enzyme in vitro and they were also able to reduce serum uric acid levels in
hyperuricemic rats. The investigation of the mechanism of action, it was found that EAL, EAB, EEB, AB
(125 and 250 mg/kg) and AL (250 mg/kg) promoted an increase on the urinary excretion of uric acid and
EEL, EEB, AB (125 and 250 mg/kg) and EAB (250 mg/kg) were capable to inhibit liver xanthine oxidase.
Treatments with EEL (125 and 250 mg/kg) and EEB (250 mg/kg) were able to reduce edema at 48th h.
EAL and EAB (125 and 250 mg/kg) showed significant anti-inflammatory activity on monosodium urate
crystal-induced paw edema model at all evaluated times.
Results: The extracts of P. pseudocaryophyllus evaluated showed expressive results regarding the inhibitionof xanthine oxidase enzyme in vitro and they were also able to reduce serum uric acid levels inhyperuricemic rats. The investigation of the mechanism of action, it was found that EAL, EAB, EEB, AB(125 and 250 mg/kg) and AL (250 mg/kg) promoted an increase on the urinary excretion of uric acid andEEL, EEB, AB (125 and 250 mg/kg) and EAB (250 mg/kg) were capable to inhibit liver xanthine oxidase.Treatments with EEL (125 and 250 mg/kg) and EEB (250 mg/kg) were able to reduce edema at 48th h.EAL and EAB (125 and 250 mg/kg) showed significant anti-inflammatory activity on monosodium uratecrystal-induced paw edema model at all evaluated times.
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