14 Conclusion
The misuse of AAS by athletes at the Olympic Games commenced some years before these substances were prohibited in sport in 1974. When subject to doping controls, AAS remain the commonest category of pharmacological agent detected in athletes' urines and at Summer Olympic Games of 2000 and 2004. The contest between anti-doping agencies and doped athletes and their pharmacological and medical supporters has continued for several decades and shows no sign of diminishing. Endocrinologists need to be mindful when confronted by athletes who seek T replacement for low-normal or age-reduced serum T levels. Occasionally, athlete-patients will be encountered who have a completely valid justification for T replacement therapy and the TUE system is designed to serve their medical needs while defending the fairness of elite sports.