Pharmaceuticals present in the aquatic environment possess high potential to harm human beings or the ecosystem, although their long-term risk requires more research. Thus, investigations on removing pharmaceuticals from the environment have been carried out recently. Though the concentrations of pharmaceuticals present in waters are normally in the range of nanograms per litre (ng/l) to microgram per litre (mg/l), in a preliminary treatment study, the initial concentrations of pharmaceuticals could be set up to 100 microgram/l . Gas and liquid chromatography (GC/LC) coupled with mass spectrometry (MS) are widely used to analye pharmaceuticals, but they become time and cost-consuming if the study aims at assessing the removal of the selected pharmaceuticals from model wastewater. Thus a simple and economic technique is assessed for the detection of ibuprofen and ciprofloxacin in the microgran/l range in model wastewater