In the literature, a number of reports exists dealing withthe capability of molds and bacteria to efficiently reduce the phenolic com-pounds content in OMW-based media. Higher fungi have thepotential to secrete extra-cellular ligninolytic enzymes (oxidases)like laccase, lignin peroxidase and manganese dependen to break down phenolic compounds. These enzymescannot be found in wild S. cerevisiae strains. A possible expla-nation for the reduction of the phenolic compounds duringcultivation of S. cerevisiae on OMW/molasses blends could be