Carbon tetrachloride produces significant reduction in catalase, GSH, SOD and peroxidase with a significant increase in MDA formation. CCl4 causes changes in liver marker enzymes by damaging the liver parenchymatous cells. It was found that administration of CCl4 0.5 ml/kg p.o., once daily for 7 consecutive days, produced a marked fall in antioxidant enzymes, proteins and glutathione and increased lipid peroxidation in vehicle-treated positive control animals. These effects indicate the extent of damage caused to hepatocellular parenchyma. CCl4 intoxication significantly lowered hepatic protein levels. These hepatic protein levels significantly (P<0.05, P<0.001) increased in the drug- treated groups when compared with the hepatotoxic control group.
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