The expression of galectin-1 was examined in 148 human primary prostate carcinoma samples [33]. Immunohistochemical
staining of paraffin sections of prostate tissues revealed that galectin-1 was not detected in normal, intraepithelial neoplasia or carcinoma cells, but accumulated in the stroma and associated fibroblasts.
The association between high expression of galectin-1 in the stroma of the malignant tissue and aggressiveness of the tumor emphasizes the role played by galectin-1 in the acquisition of the invasive phenotype.