There is a high rate of amphetamine psychosis (32.1%) among patients with 1st episode schizophrenia. We recommend hospitalization of patients for the purpose of clarifying the diagnosis. This study confirms that urine screen for amphetamine must be routine for each patient with acute psychosis especially in areas where amphetamine abuse is common. The diagnostic differences between amphetamine psychosis and other psychoses are very important, as amphetamine psychosis requires a different management. Clinicians must be trained on how to differentiate between amphetamine psychosis and other psychoses regarding clinical, personality and demographic profile. This study also extends the previously reported association of personality disorders with amphetamine psychosis and other psychoses. Detecting the prevalence of amphetamine abuse among patients of acute psychosis and clarifying the psychotic features related to this disorder will decrease the budget and help in legal and forensic aspects and it will also increase the doctors’ awareness and efficiency in dealing with those patients.