Granule cells are smaller insize and their limited volume of cytoplasm might represent an important clue towards understanding their vulnerability towards MeHg-induced damage. It means that there is less binding sites for mercury and thus critical concentration at sensitive sites might be reached earlier during exposure.e.
For the cytoskeletal proteins, primarily the microtubules, the distance between the outer cell membrane and the nucleus is very short and we may speculate that even limited depolymerization of the microtubules will have a profound effect on cellular metabolism and mitochondrial activity.