INTRODUCTION
Amanita mushroom poisoning is the most serious toxic mushroom ingestion, resulting in almost all mushroomrelated fatalities. The toxins responsible are α-amanitin, β-amanitin, and γ-amanitin.
The amanitins are cyclic polypeptides with a 6-hydroxyl-substituted indole residue bridging the peptide ring(Figure). α-,β-,and γ-amanitins only differ by minor substitutions in the peptide ring, not in the central indole residue. Amanita cyclopeptides (α-,β-,and γ-amanitin) inhibit RNA polymerase II, Which is the enzyme responsible of messenger RNA synthesis.