Histological changes in ankle joints of arthritic control animal. Section of joint cavity showing severe periarticular inflammation with marked edema is present with areas of bone resorption (double arrow) as well as the damaged articular cartilage (single arrow) (B) Histological changes in ankle joints of animal treated with MEBL 300mg/kg BW, i.p. Periarticular inflammation is there but it is less than the arthritic control (double arrow is showing the periarticular inflammation along with edema). Damaged articular cartilage is repairing (single arrow). (C) Histological changes in ankle joints of animal treated with MEBL 600mg/kg BW, i.p. Periarticular inflammation is gradually recovering (double arrow is showing the periarticular inflammation along with less edema). Articular cartilage is repairing (single arrow). (D) Histological changes in ankle joints of animal treated with standard drug indomethacin 10mg/kg BW, i.p. Periarticular inflammation is very less double arrow is presenting the position. Articular cartilage is largely unaffected.