Once the workhorse caspases are activated, a subset of the total cellular
polypeptides begin to be selectively degraded. The currently identified
caspase substrates are listed in Table 11.1 of Chapter 11 by Kaufmann et al.
Although it remains to be shown that any particular cleavage event is absolutely
essential for the demise of the cell, the net effect of all of the cleavage
events appears to be cell death.
17a,48,63