strepotolysin A and deoxyri-bonuclease B are two further proteins that generate antibody formation on infection with GAS. in absence of clinical manifestations, measurement or the antibodies for these two antigens(ASO and Anti-DNaseB) can indicate recent GAS infecticn. It is impor-tant the antibody titre be repeated 10 to 14 days after first measurs-ment if the first results were low-rising titres indicate infection,while persistent low titres are associated with carrier status or chronic infection