3.2. Effect of CSP on H22 tumor growth in vivo
To further investigate whether CSP exerted an in vivo antitumor
activity, H22 xenograft tumors were excised from each group and
weighed following 10 day’s CSP pretreatment at dose of 50, 100
and 200 mg/kg. The antitumor effect of CSP on H22 tumor-bearing
mice is summarized in Table 1. At the end of the study, the average
tumor weight in the model control group was 2.34 ± 0.35 g.
Compared to model control group, the tumors weight in the CSP
groups was significantly decreased to 1.23 ± 0.33 g for 50 mg/kg
(P < 0.01), 1.39 ± 0.41 g for 100 mg/kg (P < 0.01) and 1.41 ± 0.40 g
(P < 0.01) for 200 mg/kg (P < 0.01), respectively. The tumor weights
in the CSP groups were not significantly different to the cisplatin
group (1.13 ± 0.31 g). Accordingly the tumor inhibitory rates of the
CSP and cisplatin-treated groups were 47.44%, 40.60%, 39.74% and
51.71%, respectively