trace metals and phosphate), which synergistically influence
the fermentation performance (36).
According to Habison et al. (26) and Rohr and Kubicek
(87), a deficiency of manganese, or phosphate and nitrogen
limitation, inhibits the A. niger anabolism, and the resulting
degradation of proteins leads to increased ammonium ion
concentration. This increase is able to counterbalance the
inhibition exerted by citric acid on phosphofructokinase (26),
being a positive end-effector (6, 25). High concentrations of
NH4
+ and glucose also repress the synthesis of -ketoglutarate
dehydrogenase, inhibiting the citric acid catabolism via the
Krebs cycle, leading to its accumulation (87). Therefore, one of
the reasons for the accumulation of citric acid is the result of
high speed flow of income and a reduction in outflow velocity
(Figure 2). But, other observations appear to contradict these
assumptions (81).
trace metals and phosphate), which synergistically influencethe fermentation performance (36).According to Habison et al. (26) and Rohr and Kubicek(87), a deficiency of manganese, or phosphate and nitrogenlimitation, inhibits the A. niger anabolism, and the resultingdegradation of proteins leads to increased ammonium ionconcentration. This increase is able to counterbalance theinhibition exerted by citric acid on phosphofructokinase (26),being a positive end-effector (6, 25). High concentrations ofNH4+ and glucose also repress the synthesis of -ketoglutaratedehydrogenase, inhibiting the citric acid catabolism via theKrebs cycle, leading to its accumulation (87). Therefore, one ofthe reasons for the accumulation of citric acid is the result ofhigh speed flow of income and a reduction in outflow velocity(Figure 2). But, other observations appear to contradict theseassumptions (81).
การแปล กรุณารอสักครู่..
