So we decided to use this dose of methylphenidate and could find significant characteristic stereotypy behavior (sniffing, gnawing, paw licking) and also a hyper locomotion response. It is suggested that methylphenidate, like amphetamine, promotes a dose-
dependent increase in extracellular dopamine in the caudate putamen and extracellular norepinephrine in the hippocampus, but has no effect on 5-HT. Methylphenidate binds to the dopamine transporter and inhibits dopamine uptake with a potency similar to that of cocaine.