Avian necrotic enteritis (NE) is an intestinal disease caused by Clostridiumperfringens and represents one of themost economically important infectious diseases affecting the world's poultry industry. Over the past several decades,prophylactic use of in-feed antibiotics has had a major impact on controlling the incidence of NE. However, regulatory and voluntary
restrictions on the use of antibiotics in poultry have led to a reemergence of NE during commercial poultry production. Alternatives to antibiotics that have shown promise in controlling avian NE include prebiotics, probiotics, symbiotics,plant extracts, feed enzymes, bacteriophage, bacterial lysins and antimicrobial peptides